EURL ECVAM Genotoxicity and Carcinogenicity Consolidated Database of Ames Negative Chemicals

The EURL ECVAM Genotoxicity and Carcinogenicity Consolidated Database is a structured master database that compiles available genotoxicity and carcinogenicity information, originating from different sources, for substances tested in the bacterial reverse mutation test (Ames test). The JRC presents here a new curated collection of 211 substances eliciting negative results in the Ames test. The collection adds to the previously published EURL ECVAM Genotoxicity and Carcinogenicity Consolidated Database of Ames positive substances (https://data.jrc.ec.europa.eu/dataset/jrc-eurl-ecvam-genotoxicity-carcinogenicity-ames) that has become, over the years, a reference for a number of activities in the area of genotoxicity testing across different product-type sectors, including regulatory initiatives, exploratory projects, development of testing strategies, and validation of new genotoxicity tests. Detailed information on the data and construction of the database are reported in Madia et al. 2020 https://doi.org/10.1016/j.mrgentox.2020.503199, recently published in Mutation Research - Genetic Toxicology and Environmental Mutagenesis journal. On October 29, 2020, the database was updated. The overall call for Benzoin, in vivo UDS, should be [-]. Thus, in the table: Column CC, row 31: change “[+] in rat hepatocytes#Glauert et al. 1985” to “[+] in vitro rat hepatocytes#Glauert et al. 1985” . Column CD, row 31: change “[+]” to “[-]”.