The precise knowledge of the characteristics of SARS-CoV-2 is central to the planning of COVID-19 mitigation measures. Mutations of the virus play a special role in this context. For a successful containment of the pandemic, it is therefore crucial to obtain a detailed overview of the propagation patterns of specific SARS-CoV-2 mutations and to discover new mutation at an early stage. According to the Ordinance on Molecular Genetic Surveillance of the Coronavirus SARS-CoV-2, every laboratory in Germany that sequences SARS-CoV-2 is obliged to transmit the sequence and associated metadata to the Robert Koch Institute. Technically, this transmission takes place via the German Electronic Sequence Data Hub (DESH). It should be noted that the data of the data set have not undergone any further quality control by the RKI. The data published here cannot easily be compared with the weekly report on virus variants of SARS-CoV-2 in Germany of the RKI. The data set is versioned and scientifically citable in the European research data repository Zenodo.org and on GitHub.com:<a href=‘https://doi.org/10.5281/zenodo.5139363</‘>https://doi.org/10.5281/zenodo.5139363https://github.com/robert-koch-institut/SARS-CoV-2-Sequenzdaten_aus_Deutschland
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