Hotspot propensity across mutational processes

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Dataset information

Catalog

Zenodo catalog

Country of origin

EU institutions

Updated

2023.12.21 00:00

Created

2023.01.01

Available languages

English

Keywords

mutational hotspots, cancer

Datasource

Official portal for European data link

Quality scoring

Dataset description

Mutational hotspots identified by HotspotFinder from 49 cancer types analysed in: Arnedo-Pac C, Muiños F, Gonzalez-Perez A, Lopez-Bigas N. Hotspot propensity across mutational processes. Mol Syst Biol. 2023:1-22. doi: doi.org/10.1038/s44320-023-00001-w Hotspots have been computed using somatic mutations in each cancer type, after excluding those overlapping cancer driver elements. HotspotFinder has been run with a threshold of 2 mutated samples per hotspot and using alternate specific mutations. For additional details, please check Materials and Methods and Appendix Note 1 in our manuscript. HotspotFinder code is available at: bitbucket.org/bbglab/hotspotfinder Source code to reproduce this data can be found at: github.com/bbglab/hotspot_propensity Cancer type identifiers are listed as follows: Acute Lymphoblastic Leukemia (ALL) Acute Myeloid Leukemia (AML) Adrenocortical Carcinoma (ACC) Anal Cancer (AN) Basal Cell Carcinoma (BCC) Biliary Tract (BILIARY_TRACT) Bladder/Urinary Tract (BLADDER_URI) Bone/Soft Tissue (BONE_SOFT_TISSUE) Bowel (BOWEL) CNS/Brain (BRAIN) Cervix (CERVIX) Colorectal Adenocarcinoma (COADREAD) Cutaneous Melanoma (SKCM) Cutaneous Squamous Cell Carcinoma (CSCC) Endometrial Carcinoma (UCEC) Ependymoma (EPM) Esophageal cancer (ES) Esophagus/Stomach cancers (ESOPHA_STOMACH) Glioblastoma Multiforme (GBM) Head and Neck (HEAD_NECK) High-Grade Glioma NOS (HGGNOS) Invasive Breast Carcinoma (BRCA) Kidney (KIDNEY) Liver (LIVER) Low-Grade Glioma NOS (LGGNOS) Lung (LUNG) Lung Neuroendocrine Tumor (LNET) Lymphoid Neoplasm (LNM) Medulloblastoma (MBL) Myeloid Neoplasm (MNM) Myeloproliferative Neoplasms (MPN) Neuroblastoma (NBL) Non-Hodgkin Lymphoma (NHL) Non-Small Cell Lung Cancer (NSCLC) Oligodendroglioma (ODG) Ovarian Cancer (OV) Pan-cancer (PANCANCER) Pancreas (PANCREAS) Pilocytic Astrocytoma (PAST) Pleural Mesothelioma (PLMESO) Prostate (PROSTATE) Retinoblastoma (RBL) Skin (SKIN) Small Bowel Cancer (SBC) Small Bowel Neuroendocrine Tumor (SBNET) Small Cell Lung Cancer (SCLC) Stomach cancer (ST) Thyroid (THYROID) Vulva (VULVA)

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190K+

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countries and EU institutions

2019

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for evaluation and prototypes

SLA

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