10X single-cell RNA sequencing of hematopoietic stem and progenitor cells from a dual SF3B1-mutant MDS-RS patient and a healthy donor

This dataset consists of 10X single-cell RNA sequencing data of bone marrow cells (CD34+ stem cells) obtained from two clinical visits of a dual SF3B1-mutant MDS-RS patient (Patient 1 in the associated publication: visits at 31 months post-diagnosis, with dominant SF3B1 N626D; and at 118 months post-diagnosis, with dominant SF3B1 K666N) and one healthy bone marrow donor. The objective of this data collection was to assess how the hematopoietic stem and progenitor cell compartment of this patient differed over time and as a result of changes in clonal frequency. The dataset is appoximately 80.9 GB and has filetypes txt, rds and fastq.