Data for: "Spatial evidence for carcinoma in situ (CIS) as an entity in human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC)"

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Provided by Karolinska Institutet

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Dataset information

Catalog
Karolinska Institutet catalog
Country of origin
Sweden
Updated
2026.02.27 12:20
Created
2025.06.09
Available languages
English
Keywords
Sequence Analysis, Human papillomavirus 16, Carcinoma in situ: Lip oral cavity and pharynx, Humant papillomvirus 16, Cancer in situ i läpp (munhåla och svalg), Carcinoma in situ of oral cavity oesophagus and stomach, Cancer in situ i munhåla, esofagus och magsäck, Sekvensanalys
Datasource
Official portal for European data link
Quality scoring

Dataset description

Human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (TSCC) is suggested to arise in tonsillar crypts. They also constitute a rare exception in the literature of carcinoma development, as carcinoma in situ (CIS) is not a recognized entity and dysplastic stages are not evident. Here we used spatial transcriptomics (10x Visium) on HPV-associated TSCC, cervical and HPV-independent oral cancer cases on morphological normal, dysplastic and invasive epithelium. Files included were: - histpopathological annotations - spatial data/images as a zip-file - filtered_feautre_bc_matrix.h5-file per sample
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